Lupus Anticoagulant Testing: Analysis of Discrepant Results and Preanalytical Pitfalls
نویسندگان
چکیده
منابع مشابه
Trials and tribulations in lupus anticoagulant testing.
This issue of Clinical Chemistry and Laboratory Medicine includes a report by Pradella and colleagues regarding a cooperative multicentre study to define the upper limits of normal for several tests used in the diagnostic assessment of lupus anticoagulant (LA) [1] . In total, 200 normal samples were assessed, comprising 40 from each of five centres, for a total of six functional LA assays. Each...
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In vitro experiments were conducted to determine whether the direct thrombin inhibitors argatroban and lepirudin can interfere with the results of lupus anticoagulant (LA) testing. Concentration-response curves were generated to calculate the concentration of anticoagulant that prolongs the activated partial thromboplastin time (aPTT) to 75 seconds (2.5 times the baseline average). Correspondin...
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Interlaboratory and intermethod variation in commercial and in-house tests used for the measurement of anticardiolipin antibodies (aCL) and lupus anticoagulant (LA) limit the diagnostic value of the results from these tests. This short review summarizes published and unpublished guidelines (some developed using consensus procedures) on aCL and LA testing that are aimed at decreasing assay varia...
متن کاملIndeterminate lupus anticoagulant results: Prevalence and clinical significance
BACKGROUND Reports of indeterminate lupus anticoagulant (LAC) results are common; however, no published data on their prevalence or clinical significance are available. We investigated the prevalence and clinical characteristics of patients with indeterminate LAC. METHODS We retrospectively reviewed the clinical and serologic characteristics of 256 unselected patients with LAC results. RESU...
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Phlebotomy is often addressed as a crucial process in the pre-analytical phase, in which a large part of laboratory errors take place, but to date there is not yet a consolidated methodological paradigm. Seeking literature, we found 36 suitable investigations issued between 1996 and 2016 (April) dealing with the investigation of pre-analytical factors related to phlebotomy. We found that the la...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2014
ISSN: 1943-7722,0002-9173
DOI: 10.1093/ajcp/142.suppl1.080